Uplink data indicating whether stimulation occurs are encoded by the stimulator through backscatter modulation and are demodulated at the external transceiver. When embedded in ex vivo porcine tissue, the integrated circuit efficiently harvested ultrasonic power, decoded downlink data for the stimulation parameters and generated current-controlled stimulation pulses. When cuff-mounted and acutely implanted onto the sciatic nerve of anaesthetized rats, the device conferred repeatable stimulation across a range of physiological responses. The miniaturized neural stimulator may facilitate closed-loop neurostimulation for therapeutic interventions. Electrical stimulation of the human cochlea: a preliminary report. Bioelectronic medicines: a research roadmap. Blood pressure control with selective vagal nerve stimulation and minimal side effects. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Microstimulation of afferents in the sacral dorsal root ganglia can evoke reflex bladder activity. Tibial nerve stimulation to drive genital sexual arousal in an anesthetized female rat. The vagus nerve in the neuro-immune axis: implications in the pathology of the gastrointestinal tract. A neural interface provides long-term stable natural touch perception. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. Review of recent advances in peripheral nerve stimulation (PNS). Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus.
Closing the loop on deep brain stimulation for treatment-resistant depression. Active sensing of target location encoded by cortical microstimulation.Ĭaudate microstimulation increases value of specific choices. A learning-based approach to artificial sensory feedback leads to optimal integration.
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Medtronic Activa PC Multi-program Neurostimulator Implant Manual 37601 (Medtronic, 2010). Medtronic Intellis Rechargeable Neurostimulator Implant Manual 97715 M946871A001 (Medtronic, 2012). NeuroPace RNS System User Manual 1015882 (NeuroPace, 2015).Ĭhristie, B. “Long-term stability of stimulating spiral nerve cuff electrodes on human peripheral nerves”. Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees. An osseointegrated human-machine gateway for long-term sensory feedback and motor control of artificial limbs. Neurosurgery: complications of DBS surgery-insights from large databases. Mechanical fatigue resistance of an implantable branched lead system for a distributed set of longitudinal intrafascicular electrodes. Wang, Y., Vaddiraju, S., Gu, B., Papadimitrakopoulos, F. Foreign body reaction to implantable biosensors: effects of tissue trauma and implant size.
The Nucleus 22-channel cochlear implant system. Zeng, F.-G., Rebscher, S., Harrison, W., Xiaoan, S. Cochlear implants: system design, integration, and evaluation. High-performance wireless powering for peripheral nerve neuromodulation systems. A sub-millimeter, inductively powered neural stimulator. A power-efficient switched-capacitor stimulating system for electrical/optical deep brain stimulation. An implantable peripheral nerve recording and stimulation system for experiments on freely moving animal subjects. A battery-less, implantable neuro-electronic interface for studying the mechanisms of deep brain stimulation in rat models. Neural dust: an ultrasonic, low power solution for chronic brain-machine interfaces. Model validation of untethered, ultrasonic neural dust motes for cortical recording.